Example of olmesartan

About olmesartan

How should I take Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide tablets? Drinking alcohol can increase certain side effects of olmesartan. Changes in body salts such as sodium and potassium and body fluids. Olmesartan may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Benicar and Toprol high. hemob.info nifedipine

Tribenzor can cause allergic reactions

PROMACTA was administered at an initial dose of 50 mg once daily for 2 weeks and increased over 2-week periods up to a maximum dose of 150 mg once daily. The efficacy of PROMACTA in the study was evaluated by the hematologic response assessed after 12 weeks of treatment. The following adverse reactions have been identified during post-approval use of the individual components of Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide tablets. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Prescribing information for olmesartan

CYP3A inducers on amlodipine. PK analysis in 28 healthy adults and 635 patients with chronic hepatitis C demonstrated that patients with chronic hepatitis C treated with PROMACTA had higher plasma AUC 0-τ values as compared with healthy subjects, and AUC 0-τ increased with increasing Child-Pugh score. Patients with chronic hepatitis C and mild hepatic impairment had approximately 100% to 144% higher plasma AUC 0-τ compared with healthy subjects. This clinical trial did not evaluate protein-binding effects. October 18, 2016. Can you take coreg and xanax - ocdwm.

Depression MAOI, drug interactions

If you take too much PROMACTA, you may have a higher risk of serious side effects. Call your healthcare provider right away. Plasma concentrations of angiotensin I and angiotensin II and plasma renin activity PRA increase after single and repeated administration of Olmesartan Medoxomil to healthy subjects and hypertensive patients. Repeated administration of up to 80 mg Olmesartan Medoxomil had minimal influence on aldosterone levels and no effect on serum potassium. Elderly patients have decreased clearance of amlodipine with a resulting increase in AUC of approximately 40% to 60%, and a lower initial dose may be required.



Olmesartan consumer information

There was a greater decrease in hemoglobin and hematocrit in patients treated with Azor as compared to patients receiving either component. There were no apparent differences in terms of SeDBP or SeSBP reductions in diabetic and non-diabetic patients treated with Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide tablets. The 7-week, randomized, double-blind period was followed by an open-label period of up to 24 weeks where patients from both arms were eligible to receive PROMACTA. The most common reason for discontinuation with Tribenzor was dizziness 1%. Olmesartan Medoxomil is a white to off-white crystalline powder. It is practically insoluble in water and sparingly soluble in methanol. Olmesartan Medoxomil is available for oral use as film-coated tablets containing 5 mg, 20 mg, or 40 mg of Olmesartan Medoxomil and the following inactive ingredients: lactose monohydrate, low-substituted hydroxypropyl cellulose, magnesium stearate, microcrystalline cellulose, and titanium dioxide. The 5 mg tablet also contains hypromellose, iron oxide yellow, polyethylene glycol, and triacetin; the 20 mg tablet also contains hypromellose and talc; the 40 mg tablet also contains polyethylene glycol, polyvinyl alcohol-part. hydrolyzed, and talc. If the potential benefit for reinitiating treatment with PROMACTA is considered to outweigh the risk for hepatotoxicity, then consider cautiously reintroducing PROMACTA and measure serum liver tests weekly during the dose adjustment phase. Hepatotoxicity may reoccur if PROMACTA is reinitiated. If liver test abnormalities persist, worsen, or recur, then permanently discontinue PROMACTA. AUC of about 60%. HCT monotherapy or who experience dose-limiting adverse reactions with hydrochlorothiazide. Tribenzor has been shown to be effective in lowering blood pressure. The three components of Tribenzor olmesartan medoxomil, amlodipine, and hydrochlorothiazide lower the blood pressure through complementary mechanisms, each working at a separate site and blocking different effects or pathways. The pharmacodynamics of each individual component is described below. Alcohol, barbiturates, or narcotics: Potentiation of orthostatic hypotension may occur. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Take olmesartan by mouth with or without food. There are no trials of Azor demonstrating reductions in cardiovascular risk in patients with hypertension, but at least one pharmacologically similar drug has demonstrated such benefits.



Low Blood Pressure hypotension

The most common signs and symptoms of hydrochlorothiazide overdose observed in humans are those caused by electrolyte depletion hypokalemia, hypochloremia, hyponatremia and dehydration resulting from excessive diuresis. If digitalis has also been administered, hypokalemia may accentuate cardiac arrhythmias. The degree to which hydrochlorothiazide is removed by hemodialysis has not been established. Warfarin: Co-administration of amlodipine with warfarin did not change the warfarin prothrombin response time. No significant drug interactions were reported in studies in which olmesartan medoxomil was coadministered with warfarin in healthy volunteers. August 13, 2016. Benicar olmesartan dosing, indications, interactions. The pharmacokinetics of olmesartan medoxomil in patients undergoing has not been studied. In patients who are elderly, volume-depleted including those on diuretic therapy or with compromised renal function, co-administration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists including olmesartan medoxomil may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Monitor renal function periodically in patients receiving olmesartan medoxomil and NSAID therapy. In some patients the administration of a NSAID can reduce the diuretic, natriuretic, and antihypertensive effects of thiazide diuretics. Therefore, monitor blood pressure closely. Talk to your doctor about other ways to lower your blood pressure if you become pregnant. PROMACTA may increase the risk of severe and potentially life-threatening hepatotoxicity. co-amoxiclav



How should I take PROMACTA?

Azor tablets contain amlodipine besylate at a dose equivalent to 5 or 10 mg amlodipine and olmesartan medoxomil in the strengths described below. Possible Interactions with: Turmeric. Eltrombopag is absorbed with a peak concentration occurring 2 to 6 hours after oral administration. Based on urinary excretion and biotransformation products eliminated in feces, the oral absorption of drug-related material following administration of a single 75-mg solution dose was estimated to be at least 52%. Distributed by: Novartis Pharmaceuticals Corporation East Hanover, New Jersey 07936. An AT2 receptor is found also in many tissues, but this receptor is not known to be associated with cardiovascular homeostasis. Olmesartan medoxomil. Of the total number of hypertensive patients receiving olmesartan medoxomil in clinical studies, more than 20% were 65 years of age and over, while more than 5% were 75 years of age and older. No overall differences in effectiveness or safety were observed between elderly patients and younger patients. Other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. Blockade of the renin-angiotensin system with ACE inhibitors, which inhibit the biosynthesis of angiotensin II from angiotensin I, is a mechanism of many drugs used to treat hypertension. ACE inhibitors also inhibit the degradation of bradykinin, a reaction also catalyzed by ACE. Because olmesartan does not inhibit ACE kininase II it does not affect the response to bradykinin. Whether this difference has clinical relevance is not yet known. In hemodynamic studies, amlodipine has not been associated with a negative inotropic effect when administered in the therapeutic dose range to intact animals and man, even when co-administered with beta-blockers to man. Similar findings, however, have been observed in normals or well-compensated patients with heart failure with agents possessing significant negative inotropic effects. Atorvastatin: Co-administration of multiple 10 mg doses of amlodipine with 80 mg of atorvastatin resulted in no significant change in the steady state pharmacokinetic parameters of atorvastatin. Ames bacterial mutagenicity test. So happy to chat with you today and learn about your interests. Looking forward to following your science writing work! Amlodipine. Experimental data suggests that amlodipine binds to both dihydropyridine and nonhydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects can be detected in vitro but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with do not feel sick. Population pharmacokinetic analysis indicated that female patients had approximately 15% smaller clearances of olmesartan than male patients. Gender had no effect on the clearance of amlodipine. Olmesartan medoxomil. Amlodipine and Olmesartan Medoxomil tablets contains olmesartan, a drug that inhibits the renin-angiotensin system RAS. Drugs that inhibit the RAS can cause hyperkalemia. Monitor serum electrolytes periodically. Consumer information and patient comments on prescription drugs.



East Asian patients in this age range

Eighty-six percent of patients were RBC transfusion dependent and 91% were platelet transfusion dependent. The majority of patients 84% received at least 2 prior immunosuppressive therapies. Three patients had cytogenetic abnormalities at baseline. What are the ingredients in Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide tablets? This medication may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist. Interaction between Benicar and Xanax: Interaction not known, but may still exist. Always consult your doctor before taking these medications together. Call your doctor for medical advice about side effects. Blood pressure should be closely monitored when amlodipine is co-administered with CYP3A inducers. Severe diarrhea and weight loss. buy zentel 500 mg



Olmesartan brand names

Limited data are available related to overdosage of olmesartan medoxomil in humans. The most likely manifestations of overdosage would be hypotension and tachycardia; bradycardia could be encountered if parasympathetic vagal stimulation occurs. If symptomatic hypotension should occur, supportive treatment should be initiated. The dialyzability of olmesartan is unknown. Severe sweating, diarrhea, or vomiting can increase the risk for lightheadedness or a serious loss of body water dehydration. Report prolonged diarrhea or vomiting to your doctor. To prevent dehydration, drink plenty of fluids unless your doctor directs you otherwise. Know the medicines you take. Keep a list of your medicines and show it to your doctor or pharmacist when you get a new medicine. This medication may interfere with certain laboratory tests including parathyroid function possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug. Cholestyramine and Colestipol Resins: Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins. Single dose of either cholestyramine or colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85% and 43%, respectively. Decrease the daily dose by 25 mg. Wait 2 weeks to assess the effects of this and any subsequent dose adjustments.



Before taking olmesartan

Elimination from the plasma is biphasic with a terminal elimination half-life of about 30 to 50 hours. Ten percent of the parent compound and 60% of the metabolites are excreted in the urine. The blood pressure lowering effect of olmesartan medoxomil, with and without hydrochlorothiazide, was maintained in patients treated for up to 1 year. There was no evidence of tachyphylaxis during long-term treatment with olmesartan medoxomil or rebound effect following abrupt withdrawal of olmesartan medoxomil after 1 year of treatment. The overall incidence of adverse reactions on therapy with Amlodipine and Olmesartan Medoxomil tablets was similar to that seen with corresponding doses of the individual components of Amlodipine and Olmesartan Medoxomil tablets, and to placebo. Olmesartan medoxomil. Changes in renal function may be anticipated in susceptible individuals treated with olmesartan medoxomil as a consequence of inhibiting the renin-angiotensin-aldosterone system. Step 11. Giving a dose of PROMACTA for oral suspension to a child. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. There is no information on overdosage with Azor in humans. TV” on one side and with “7612” on the other side, containing 40 mg of Olmesartan Medoxomil. Potassium salts were filtered off from the reaction mass and the filtrate was charcoalised for 1hr. It was filtered over celite bed and the filtrate was distilled off completely to get a semi solid mass. 250 ml of Methanol was added to the residue and stirred for 2-3 hrs to give a solid product, which was filtered and washed with chilled methanol and dried. I've been placed on Xanax. Untreated can lead to permanent vision loss. Hydrochlorothiazide. Hydrochlorothiazide is a thiazide diuretic. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. Indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume, with consequent increases in plasma renin activity, increases in aldosterone secretion, increases in urinary potassium loss, and decreases in serum potassium. The renin-aldosterone link is mediated by angiotensin II, so co-administration of an angiotensin II receptor antagonist tends to reverse the potassium loss associated with these diuretics. Amlodipine does not change sinoatrial nodal function or conduction in intact animals or man. Take PROMACTA tablets whole. Do not crush PROMACTA tablets and mix with food or liquids. If you miss a dose of PROMACTA, wait and take your next scheduled dose. Do not take more than one dose of PROMACTA in one day. example of verapamil



Does olmesartan interact with other medications

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity, and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Benicar HCT as soon as possible. These adverse outcomes are usually associated with use of these drugs in the second and third trimester of pregnancy. Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. Appropriate management of maternal hypertension during pregnancy is important to optimize outcomes for both mother and fetus. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. October 16, 2016. Real Benicar 20mg Olmesartan Olmesartan Medoxomil. Changes in renal function including acute renal failure can be caused by drugs that inhibit the renin-angiotensin system and by diuretics. Take this by as directed by your doctor, usually once daily with or without food. The dosage is based on your medical condition and response to treatment. Olmesartan Medoxomil tablets are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including the class to which this drug principally belongs. There are no controlled trials demonstrating risk reduction with Olmesartan Medoxomil tablets. Amlodipine. The pharmacokinetics of amlodipine are not significantly influenced by renal impairment. Patients with renal failure may therefore receive the usual initial dose. No dose adjustments are recommended. Drug interactions with other HCV protease inhibitors have not been evaluated.



Indications and usage of olmesartan

PROMACTA plus antivirals 7% than the placebo plus antivirals arm 4%. Azor is not recommended in hepatically impaired patients. January 11, 2017. olmesartan oral Benicar Oral Drug Interactions. The majority of events were of the portal venous system 1% in patients treated with PROMACTA versus less than 1% for placebo. Learn about drug interactions between olmesartan oral and spironolactone oral and use the RxList drug interaction checker to check drug combinations. Dizziness or lightheadedness may occur as your body adjusts to the medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. How should I store PROMACTA for oral suspension? pramipexole



Highlights for olmesartan

Before using this medication, tell your doctor or pharmacist your medical history, especially of: gout, kidney disease, liver disease, lupus, severe loss of body water and minerals dehydration. PROMACTA in an attempt to normalize platelet counts. Eye problems. One of the medicines in Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide tablets can cause eye problems that may lead to vision loss. Symptoms of eye problems can happen within hours to weeks of starting Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide tablets. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Hydrochlorothiazide may alter glucose tolerance and raise serum levels of cholesterol and triglycerides. Project organized to promote the rights of street vendors. Includes FAQ. There was a greater decrease in and in the combination product compared to either component. Other laboratory changes can usually be attributed to either monotherapy component.



General information about olmesartan

PREGNANCY and BREAST-FEEDING: Olmesartan may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. It is not known if this medicine is found in breast milk. Do not breast-feed while taking olmesartan. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. Monitor serum electrolytes periodically. Start with the plunger pushed all the way into the syringe. See for dosing recommendations for pediatric patients 1 year and older. The safety and efficacy of PROMACTA in pediatric patients younger than 1 year with ITP have not yet been established. Answers - Posted in: advil, aleve, percocet, interaction - Answer: The percs are ok with either one of the others. Turner Gas Company is family-owned and has successfully served customers for over 75 years. We are the market leader in energy and chemical transportation, marketing. The pharmacokinetics of Amlodipine and Olmesartan Medoxomil from Amlodipine and Olmesartan Medoxomil tablets are equivalent to the pharmacokinetics of Amlodipine and Olmesartan Medoxomil when administered separately. The bioavailability of both components is well below 100%, but neither component is affected by food. Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide tablets. See the end of the leaflet for a list of the ingredients in Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide tablets. Hydrochlorothiazide decreases urinary calcium excretion and may cause elevations of serum calcium. Monitor calcium levels. Tap the top of each packet to make sure the contents fall to the bottom. The placebo-subtracted incidence of edema during the 8-week, randomized, double-blind treatment period was highest with amlodipine 10 mg monotherapy. The incidence was significantly reduced when 20 mg or 40 mg of olmesartan medoxomil was added to the 10 mg amlodipine dose. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. It is not known whether the amlodipine or olmesartan medoxomil components of Amlodipine and Olmesartan Medoxomil tablets are excreted in human milk, but olmesartan is secreted at low concentration in the milk of lactating rats. Because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother. Angiotensin II is formed from angiotensin I in a reaction catalyzed by ACE, kininase II. xtane buy online australia



Buy olmesartan 500 mg

where can i buy olmesartan perfect measure, generic olmesartan order shopping canada, price of olmesartan stock, cheapest olmesartan order payment europe, pharmacy has cheapest olmesartan, purchase cheapest olmesartan shopping australia, brand for olmesartan, purchase olmesartan 40 mg, buy olmesartan shopping otc, olmesartan online rezept, cheap olmesartan order pharmacy uk, buy olmesartan payment canada, generic olmesartan legitimate, over the counter olmesartan, is there a generic pill for olmesartan, olmesartan mexico, cheap olmesartan buy store europe, price of olmesartan in dubai, order olmesartan to canada, drugs similar to olmesartan, olmesartan generic name brand, order olmesartan online, olmesartan online einkaufen, can you olmesartan at boots, walmart olmesartan, order canadian olmesartan, purchase olmesartan reacoes, mercury olmesartan, cheap olmesartan buy now pharmacy, generic olmesartan lowest price, walmart canada olmesartan, olmesartan mail order now shopping, olmesartan purchase online mastercard australia, price olmesartan mexico, how much does olmesartan pharmacy, olmesartan where to purchase uk, where to purchase olmesartan pharmacy, olmesartan cost private prescription, olmesartan closeouts, buy olmesartan royal, price olmesartan review, pharmacy olmesartan now, store olmesartan kada, shop olmesartan review, generic olmesartan pharmaceuticals, generic olmesartan walgreens, olmesartan drug, buy cheapest olmesartan online uk, cost of olmesartan without insurance 2016, olmesartan how to purchase mastercard, olmesartan street price per pill, olmesartan order store australia, olmesartan thailand, olmesartan price giant eagle, can you buy olmesartan under 18, olmesartan shop in melbourne, olmesartan cheap australia, buy olmesartan brampton, olmesartan brand for dogs, where to get olmesartan in australia, is there a generic brand for olmesartan, olmesartan 500 mg, olmesartan purchase mastercard, order olmesartan from canadian pharmacy, olmesartan store las vegas, purchase generic olmesartan pharmacy usa, olmesartan 100mg tab, cheap olmesartan price, himalaya olmesartan india, buy olmesartan 500 mg, example of olmesartan, olmesartan buy online australia, purchase olmesartan uses

Olmesartan dosage


Use of olmesartan

Tell your doctor if you develop any new symptoms. CV disease. The trial met its primary endpoint, delayed onset of microalbuminuria, but olmesartan had no beneficial effect on decline in filtration rate GFR. Gender: Minor differences were observed in the pharmacokinetics of olmesartan in women compared to men. AUC and C max were 10-15% higher in women than in men. purchase proventil uses

How to use olmesartan

The overall frequency of adverse events was not dose-related. Analysis of gender, age, and race groups demonstrated no differences between olmesartan medoxomil- and placebo-treated patients. Olmesartan Medoxomil for hypertension. Ulcerative Colitis - HealingWell. Olmesartan Medoxomil tablets for hypertension. Blockade of the angiotensin II receptor inhibits the negative regulatory feedback of angiotensin II on renin secretion, but the resulting increased plasma renin activity and circulating angiotensin II levels do not overcome the effect of olmesartan on blood pressure.

How should i take olmesartan

There is some information that Xanax. DXY taking both xanax and klonopin A Moderate Drug Interaction exists between Ambien and Xanax. View detailed information regarding th. Jul 25, 2013. After oral administration of therapeutic doses of amlodipine, absorption produces peak plasma concentrations between 6 and 12 hours. Absolute bioavailability is estimated as between 64% and 90%. If you have any questions about olmesartan, please talk with your doctor, pharmacist, or other health care provider.

Manufactured for Daiichi Sankyo, Inc

In patients who are elderly, volume-depleted including those on diuretic therapy or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists, including Olmesartan Medoxomil, may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Monitor renal function periodically in patients receiving Olmesartan Medoxomil and NSAID therapy. Use the lowest dose of PROMACTA to achieve and maintain a platelet count necessary to initiate and maintain antiviral therapy with pegylated interferon and ribavirin. Dose adjustments are based upon the platelet count response.

Benicar and grapefruit interaction. Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function including acute renal failure compared to monotherapy. Most patients receiving the combination of two RAS inhibitors do not obtain any additional benefit compared to monotherapy. In general, avoid combined use of RAS inhibitors. Closely monitor blood pressure, renal function and electrolytes in patients on Olmesartan Medoxomil and other agents that affect the RAS. QTc prolonging effect of PROMACTA at doses up to 150 mg daily for 5 days.

Learn more »